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Primary Examiner: Myers, Jane S.
Assistant Examiner:
Attorney: Krubiner; Alan M., Walker; William B.

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Title: Methods and compositions for the use of 2-carboxy-5-oxo-5H-dibenzo[a,d]cycloheptenes, salts and esters thereof

Abstract: 2-Substituted-5-oxo-5H-dibenzo[a,d]cycloheptenes represented by the following formula: ##STR1## where R' is hydrogen, alkyl having 1 to 12 carbon atoms, or ##STR2## where n is an integer from 2 to 4, inclusive, and R.sup.4 and R.sup.5 are independently lower alkyl having 1 to 6 carbon atoms or together R.sup.4 and R.sup.5 and the nitrogen atom to which they are attached form a heterocyclic ring having 5 or 6 total ring atoms; and the pharmaceutically acceptable salts thereof. The compounds are useful in the treatment of auto-immune diseases and allergic reactions.

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Inventors: Nelson, Peter H. (Los Altos, CA, US)
Untch, Karl G. (Los Altos, CA, US)

Application Number: 564001
Filing Date: 1975-03-31
Publication_date: 1977-07-12
Assignee: Syntex (U.S.A.) Inc. (Palo Alto, CA)
Primary Class(es): 514/569 514/534, 514/544, 514/825, 514/826, 514/885, 536/55.2, 544/154, 544/275, 544/380, 546/204, 548/528, 560/51, 562/461
Other Classes:
US Patent Ref:

3256335	Jun, 1966	Slates et al.	260/469.
3468939	Sep, 1969	Kaltenbionn	260/515.
3600437	Aug, 1971	Marshall	260/520.
3624142	Nov, 1971	Shen et al.	260/515.
3641134	Feb, 1972	Shen et al.	260/520.
3803234	Apr, 1974	Dostert et al.	260/469.
3864493	Feb, 1975	Cairns et al.	424/283.
3879544	Apr, 1975	Reisner et al.	424/337.
3883593	May, 1975	Berezin et al.	260/590.
3883653	May, 1975	Barth	424/251.
3885038	May, 1975	Pfister et al.	424/283.

Other Refs: Other References: Gomes, C. R. Acad. Sc. Paris, t.274, Serie C, pp. 73-76 (1976).
The Merck Manual, pp. 612-617, 1209-1219 and 1252-1255.
Ebnoether et al., as cited in C.A. 63, 17997 (1965).