Title: 10-[.omega.-(BENZOYLPIPERIDINYL)ALKYL]PHENOTHIAZINES

Abstract: 10-[.omega.-(Benzoylpiperidinyl)alkyl]phenothiazines having the formula ##STR1## wherein R is hydrogen, chloro, bromo, trifluoromethyl, lower alkoxy, acetyl, sulfamoyl, or dimethylsulfamoyl, R.sup.1 is hydrogen, chloro, bromo, fluoro, trifluoromethyl, lower alkyl or lower alkoxy and n is 2, 3 or 4 are disclosed. Methods for the preparation of the compounds are described. The compounds possess tranquilizing activity and are useful as tranquilizing agents in mammals.

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Inventors: Welstead, Jr., William J. (Richmond, VA, US)
Boswell, Jr., Robert F. (Richmond, VA, US)

Application Number: 678575
Filing Date: 1976-04-20
Publication_date: 1977-05-03
Assignee: A. H. Robins Company, Incorporated (Richmond, VA)
Primary Class(es): 514/225.5 544/46, 546/225
Other Classes:
US Patent Ref:

3225037	Dec, 1965	Zenitz et al.	260/243.
3637660	Jan, 1972	Eriksoo et al.	260/243.

Other Refs: 863,243

Mar, 1961	UK

Other References: Schenker-Herbst, Drug Research, vol. 5, pp. 288 to 289 and 419 to 426, Birkhauser Verlag Basel und Stuttgart, (1963).
Chemical Abstracts, vol. 72, Abst. No. 100535h, (1970), (Abst. of German Offen. 1,930,818).