Title: Ocular drug delivery device

Abstract: An ocular drug dispensing device for administering a drug at a controlled and continuous dosage unit rate to the eye to produce a local or systemic physiological or pharmacological effect is comprised of a shaped body insoluble in tear fluid and comprised of a first wall, a third wall distant from the first wall, a second wall interposed between the first and third wall and extending around their peripheries for sealingly engaging the first and third wall, a reservoir defined by the inner surfaces of the walls and containing the drug or a mixture of the drug in a carrier and wherein at least one of the first and third walls is formed of an imperforate drug release rate controlling material permeable to the passage of drug or a microporous material containing in the micropores a drug release rate controlling medium permeable to the passage of drug for administering a therapeutically effective amount of drug over a prolonged period of time.

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Inventors: Arnold, Randall K. (San Jose, CA, US)

Application Number: 670267
Filing Date: 1976-03-25
Publication_date: 1977-03-29
Assignee: Alza Corporation (Palo Alto, CA)
Primary Class(es): 424/427 604/294
Other Classes:
US Patent Ref:

3641237	Feb, 1972	Gould et al.	128/260.
3699963	Oct, 1972	Zaffaroni	128/268.
3710795	Jan, 1973	Higuchi et al.	128/130.
3960150	Jun, 1976	Hussain et al.	128/260.
3961628	Jun, 1976	Arnold	128/260.
3967618	Jul, 1976	Zaffaroni	128/130.
3972995	Aug, 1976	Tsuk et al.	428/28.

Other Refs:
Primary Examiner: Medbery, Aldrich F.
Assistant Examiner:
Attorney: Sabatine; Paul L., Ciotti; Thomas E., Mandell; Edward L.