Title: Snake venom inhibitor material and method of purification

Abstract: A material extracted from snakes such as snake serum is purified to obtain an inhibitor for snake venom toxicity and/or proteolytic enzymes. Snake serum is treated to obtain a useful therapeutic agent present in the serum and attached to a high molecular weight protein molecule. The protein molecule is split and fragments thereof are removed along with unwanted antigenic protein material to thus separate a purified material having high inhibitor activity against snake venom toxicity and proteases. The resulting inhibitor material is relatively low in protein content with an increase of specific activity of many times that of crude serum.

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Inventors: Philpot, Jr., Van B. (Houston, MS, US)

Application Number: 566995
Filing Date: 1975-04-10
Publication_date: 1977-03-15
Assignee:
Primary Class(es): 424/531 424/542, 435/269
Other Classes:
US Patent Ref:

3504083

Mar, 1970

Philpot

424/101.

Other Refs:
Primary Examiner: Friedman, Stanley J.
Assistant Examiner:
Attorney: Cushman, Darby & Cushman