Title: Drug excipient of silicone rubber

Abstract: Nontoxic sustained release pharmaceutical compositions containing one or more nonionic, lipophilic drugs in a cured low temperature vulcanizable (LTV) silicone elastomer excipient are prepared substantially free of toxic vulcanizing agents or drug-reactive by-products in the elastomeric material by curing with a vulcanizable composition comprising A. a polydimethylsiloxane having vinyl groups on both ends; B. a copolymer consisting essentially of SiO.sub.2 units, (CH.sub.3).sub.3 SiO.sub.0.5 units, Vinyl(CH.sub.3).sub.2 SiO.sub.0.5 units; and C. a cross-linking Si-H component, consisting essentially of (CH.sub.3).sub.3 SiO.sub.0.5 units, (CH.sub.3).sub.2 SiO units, and CH.sub.3 HSiO units. The resultant compositions are characterized by good physical properties and a constant rate of drug release in the body over long periods of time.

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Inventors: Schopflin, Gisela (Berlin, DT)

Application Number: 616001
Filing Date: 1975-09-23
Publication_date: 1977-03-15
Assignee: Schering Aktiengesellschaft (Berlin & Bergkamen, DT)
Primary Class(es): 424/432 128/833
Other Classes:
US Patent Ref:

3279996	Oct, 1966	Long et al.	424/32.
3545439	Dec, 1970	Duncan	128/130.
3920805	Nov, 1975	Roseman	424/15.

Other Refs: 2,158,226

May, 1973	DT.

Primary Examiner: Rose, Shep K.
Assistant Examiner:
Attorney: Millen & White