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Primary Examiner: Meyers, Albert T.
Assistant Examiner: Fagelson, A. P.
Attorney: Moran; Tom M., Hirsch; Joseph I.

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Title: Medicament preparations

Abstract: A pharmaceutical preparation having a minor amount of a tetracycline medicament, and a major amount of a dialkylated mono- or poly-alkylene glycol vehicle therefor, and, optionally, a minor amount of one or more antioxidants for the dialkylated glycol vehicle. The preparations are stable topical tetracycline formulations having good release and skin penetration characteristics.

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Inventors: Thompson, Geoffrey F. (Sunnyvale, CA, US)

Application Number: 623871
Filing Date: 1975-10-17
Publication_date: 1977-03-08
Assignee: Syntex (U.S.A.) Inc. (Palo Alto, CA)
Primary Class(es): 514/153 568/613
Other Classes:
US Patent Ref:

2146324	Feb, 1937	Zellhoefer	260/615.
2271873	Feb, 1942	Perkins	260/615.
2520611	Aug, 1950	Roberts	260/615.
2520612	Aug, 1950	Roberts	260/615.
2943056	Jun, 1960	Bolt	260/615.
3308217	Mar, 1967	Lowy	424/227.
3591641	Jul, 1971	Ameen	260/615.
3629111	Dec, 1971	Cramer	252/75.
3751562	Aug, 1973	Nichols	424/227.
3833725	Sep, 1974	Thompson	424/227.
3846486	Nov, 1974	Marcus	424/227.
3906043	Sep, 1975	Marcus	260/559.

Other Refs: 1,296,5151,792,4481,203,611

May, 1962	FR
Mar, 1974	DT
Aug, 1970	UK

Other References: Lange, Chem. Abs. vol. 69 (1968), p. 99303k.
Agami, Chem. Abs. vol. 69 (1968), p. 76074.