Title: Prolonged release drug form for the treatment of bovine mastitis

Abstract: A prolonged release drug dosage form for the treatment of bovine mastitis, specifically suited for dry cow treatment, consists of an antimicrobial agent dispersed in a matrix of a low molecular weight polyester of glycolic and lactic acids, and shaped as a cylindrical bougie for facile insertion into the teat canal. Said polyester erodes by hydrolysis in the bioenvironment, providing a continuous release of the medication throughout the desired duration of the treatment. The low molecular weight polyesters have a glycolic acid content of about 60 to 80 mole percent, a lactic acid content of about 20 to 40 mole percent, and a molecular weight less than 2000.

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Inventors: Reuter, Gerald L. (Plattsburgh, NY, US)
Tsuk, Andrew G. (Plattsburgh, NY, US)

Application Number: 590358
Filing Date: 1975-06-25
Publication_date: 1977-03-08
Assignee: American Home Products Corporation (New York, NY)
Primary Class(es): 514/152 424/115, 424/116
Other Classes:
US Patent Ref:

3755558	Aug, 1973	Scribner	424/78.
3773919	Nov, 1973	Boswell et al.	424/78.
3887699	Jun, 1975	Yolles	424/78.

Other Refs:
Primary Examiner: Rosen, Sam
Assistant Examiner:
Attorney: Venetianer; Stephen