Title: Oxadiazoline derivatives

Abstract: Benzylidenehydrazono-oxadiazoline compounds have been prepared of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are both lower alkyl or form with the heterocyclic ring carbon atom an alicyclic ring; and R.sub.3 when present is selected from halogen, lower alkyl and lower alkoxy. The preparation involves condensing a benzaldehyde with carbodihydrazide and further condensing with a ketone (or vice versa) to form the corresponding crossed carbodihydrazone, and oxidizing and cyclizing to form the oxadiazoline derivatives. These derivatives have analgesic and/or anti-inflammatory activity.

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Inventors: Warkentin, John (Burlington, CA, US)
Ramakrishnan, Kottieth (Hamilton, CA, US)
Jain, Rup C. (Montreal, CA, US)
Wandelmaier, Frank W. (Montreal, CA, US)

Application Number: 628223
Filing Date: 1975-11-03
Publication_date: 1977-02-22
Assignee: Canadian Patents and Development Limited (Ottawa, CA)
Primary Class(es): 514/364 548/143
Other Classes:
US Patent Ref:

3417082	Dec, 1968	Taylor	260/240.
3784555	Jan, 1974	Cebalo et al.	260/240.

Other Refs:
Primary Examiner: Demers, Arthur P.
Assistant Examiner:
Attorney: Thomson; Alan A.