Title: N.sup.6 -Substituted-9-[3-(4-phenyl-piperazino)-propyl]-adenines

Abstract: A N.sup.6 -substituted-9-[3-(4-phenyl-piperazino)-propyl]-adenine of the formula ##STR1## wherein R.sub.1 is hydrogen or a lower alkyl radical, and R.sub.2 is a lower alkyl radical, a lower alkyl radical substituted by at least one of phenyl and hydroxyl, a lower alkenyl radical, a cycloalkyl radical or an aryl radical, or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a piperidine, pyrrolidine or morpholine ring, and R.sub.3 is hydrogen, halogen, a lower alkyl radical or a lower alkoxy radical, Or a salt thereof with a pharmacologically compatible acid, which compounds are characterized by marked anti-edematous activity as well as by activity in reducing capillary permeability.

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Inventors: Friebe, Walter-Gunar (Darmstadt, DT)
Thiel, Max (Mannheim, DT)
Winter, Werner (Viernheim, DT)
Roesch, Androniki (Mannheim, DT)
Schaumann, Wolfgang (Heidelberg, DT)

Application Number: 531420
Filing Date: 1974-12-10
Publication_date: 1976-12-07
Assignee: Boehringer Mannheim G.m.b.H. (Mannheim, DT)
Primary Class(es): 514/252.16 514/826, 544/277
Other Classes:
US Patent Ref:

3457263	Jul, 1969	Regnier et al.	260/252.
3862189	Jan, 1975	Schwender	260/252.
3917596	Nov, 1975	Winter et al.	260/252.

Other Refs: 621,979

Feb, 1963	BE

Primary Examiner: Coughlan, Jr., Paul M.
Assistant Examiner:
Attorney: Burgess, Dinklage & Sprung