Title: Secondary phosphoric acid esters

Abstract: This invention relates to novel secondary phosphoric acid esters and salts thereof, having valuable pharmacological properties, and to the preparation thereof. The invention is also concerned with pharmaceutical compositions containing the said compounds, and methods of treatment therewith. The esters are i.a. useful as selective inhibitors of prostaglandins and of Slow Reacting Substances (SRS). They also inhibit the formation of adenosine 3' ,5'-monophosphate (cyclic AMP). In addition the esters of this invention also exert intrinsic smooth muscle stimulatory activity.

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Inventors: Hogberg, Bertil (Helsingborg, SW)
Fex, Hans (Helsingborg, SW)
Perklev, Torsten (Helsingborg, SW)
Veige, Sten (Helsingborg, SW)
Fredholm, Bo (Nyhamnslage, SW)

Application Number: 280211
Filing Date: 1972-08-14
Publication_date: 1976-11-02
Assignee: Aktiebolaget Leo (Helsingborg, SW)
Primary Class(es): 514/120 514/76, 514/121, 514/130, 558/101, 558/110, 558/190, 558/192, 558/193, 558/194, 558/197, 558/198, 558/210, 987/228
Other Classes:
US Patent Ref:

3297631

Jan, 1967

Bown et al.

260/953.

Other Refs:
Primary Examiner: Sutto, Anton H.
Assistant Examiner:
Attorney: Hueschen; Gordon W.