Title: Thiazole cardiovascular agents

Abstract: 1-Amino-3-[2-thiazoloxy]-2-propanol and substituted 1-amino derivatives thereof; 3-[2-thiazoloxy]-1,2-epoxypropane 5-[thiazol-2-oxymethylene]-oxazolidine and/or N-substituted and/or 2-substituted oxazolidine, derivatives thereof and methods of preparing such compounds. The above 1-amino-3-[2-thiazoloxy]-2-propanol and derivatives exhibit .beta.-adrenergic stimulating cardiovascular activity and are useful for the treatment of abnormal heart conditions in mammals. The above 3-[2-thiazoloxy]-1,2-epoxypropane and derivatives are useful as intermediates for the aforementioned cardiovascular agents. The 5-[thiazol-2-oxymethylene]-oxazolidine and derivatives are intermediates for aforementioned cardiovascular agents. The 1-amino-3-[2-thiazoloxy]-2-propanol and derivatives can be prepared by base or acid hydrolysis of the corresponding 5-[thiazol-2-oxymethylene]-oxazolidine or derivatives; or by treatment of the corresponding 3-[2-thiazoloxy]-2,3-epoxypropane or derivative with the desired amine or amino-derivative.

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Inventors: Edwards, John A. (Los Altos, CA, US)

Application Number: 507651
Filing Date: 1974-09-19
Publication_date: 1976-09-21
Assignee: Syntex (U.S.A.) Inc. (Palo Alto, CA)
Primary Class(es): 514/369 514/236.8, 514/326
Other Classes:
US Patent Ref:

3328417	Jun, 1967	McLoughlin et al.	260/302.
3631055	Dec, 1971	Posselt et al.	260/302.
3729469	Apr, 1973	Wasson	260/293.
3850945	Nov, 1974	Edwards	260/302.

Other Refs:
Primary Examiner: Schenkman, Leonard
Assistant Examiner:
Attorney: Squires; Lawrence S., Walker; William B.