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Title: 4-Cyclopropylmethyleneoxy-3-chlorophenylacetic acid and salts thereof

Abstract: The compound 4-cyclopropylmethyleneoxy-3-chlorophenylacetic acid and its non-toxic pharmaceutically acceptable salts have activity as anti-inflammatory, antipiretic and analgesic agents. It is prepared by reacting a lower alkyl ester of 3-chloro-4-hydroxyphenyl acetic acid with a cyclopropylmethylene halide and subsequently saponifying the ester obtained. The acid obtained is optionally salified to give corresponding non-toxic, inorganic or organic pharmaceutically acceptable salts.


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Inventors: Pifferi, Giorgio (Milan, IT)

Application Number: 539912
Filing Date: 1975-01-09
Publication_date: 1976-08-24
Assignee: ISF SpA (Milan, IT)
Primary Class(es): 514/568 514/499, 514/554, 556/114, 562/465
Other Classes:
US Patent Ref:
3553226Jan, 1971Kaiser et al.260/520.
3766263Oct, 1973Godfrey260/520.
3786085Jan, 1974Dickel et al.260/520.

Other Refs: 1,174,535
Dec, 1969UK

Primary Examiner: Morgenstern, Norman
Assistant Examiner:
Attorney: Stevens, Davis, Miller & Mosher