Title: Methods of improving control of release rates and products useful in same

Abstract: Improved processes for obtaining the sustained release of pharmaceuticals from polymer matrices comprising the utilization of such steps as will allow the formation of solid solutions between pharmaceutical and its matrix or, conversely and in a proper case, substantially avoiding formation of any solid solution between the matrix and pharmaceutical. The advantage of such processes is the greater predictability of qualitative and quantitative nature of release rates of products formed therewith.

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Inventors: Sadek, Safik E. (Wayland, MA, US)

Application Number: 431493
Filing Date: 1974-01-07
Publication_date: 1976-08-24
Assignee: Dynatech Corporation (Burlington, MA)
Primary Class(es): 424/425 424/423, 424/486, 604/500, 606/231
Other Classes:
US Patent Ref:

3225766	Dec, 1965	Baptist et al.	128/260.
3435008	Mar, 1969	Schmitt et al.	260/78.
3545439	Dec, 1970	Duncan	128/260.
3630200	Dec, 1971	Higuchi	128/260.
3641237	Feb, 1972	Gould et al.	424/16.
3773919	Nov, 1973	Boswell et al.	424/19.
3810458	May, 1974	Semp	128/260.
3811444	May, 1974	Heller	128/260.
3887699	Jun, 1975	Yolles	424/19.

Other Refs: 2,218,200

Oct, 1972	DT

Primary Examiner: Medbery, Aldrich F.
Assistant Examiner:
Attorney: Cesari and McKenna