Title: 2-Substituted-5-oxo-5H-dibenzo(a,d)cycloheptenes, and derivatives thereof, and methods and compositions for the use thereof

Abstract: 2-Substituted-5-oxo-5H-dibenzo[a,d]cycloheptenes represented by the following formula: ##SPC1## Where one of R.sup.2 and R.sup.3 is hydrogen, and the other is hydrogen, methyl, or ethyl, or together R.sup.2 and R.sup.3 are methylene; and R' and R.sup.4 are alkoxy, or together R' and R.sup.4 are =O, =NOH, =NNHCONH.sub.2, or alkylenedioxy of the formula --O--CH.sub.2 --(CR.sup.5.sub.2).sub.n --CH.sub.2 --O-- where n.sub.5 is O--2, R.sup.5 is hydrogen or methyl when n is 1, and R.sup.5 is hydrogen when n is 2, or one of R' and R.sup.4 is --OH and the other is (SO.sub.3 Y) where Y is sodium or potassium. The compounds have anti-inflammatory, analgesic and anti-pyretic activities and, accordingly, are useful in the treatment of inflammation, pain and pyrexia.

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Inventors: Nelson, Peter H. (Los Altos, CA, US)
Untch, Karl G. (Los Altos, CA, US)

Application Number: 572477
Filing Date: 1975-04-28
Publication_date: 1976-08-17
Assignee: Syntex (U.S.A.) Inc. (Palo Alto, CA)
Primary Class(es): 514/577 514/590, 514/640, 514/645, 514/680, 514/887, 514/916, 562/41, 564/36, 564/265, 568/316, 568/326, 568/439
Other Classes:
US Patent Ref:

3372192	Mar, 1968	Engelhardt	260/590.
3478048	Nov, 1969	Edenhofer et al.	260/590.
3551498	Dec, 1970	Tristram et al.	260/590.
3697581	Oct, 1972	Hummer	260/590.
3833655	Sep, 1974	Edenhofer et al.	260/590.
3836585	Sep, 1974	Tristram et al.	260/511.
3883592	May, 1975	Berezin et al.	260/590.

Other Refs:
Primary Examiner: Thomas, Jr., James O.
Assistant Examiner: Reamer, James H.
Attorney: Hirsch; Joseph I., Walker; William B.