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Title: 6.beta.,17-Dihydroxy-7.alpha.-(lower alkoxy)carbonyl-3-oxo-17.alpha.-pregn-4-ene-21-carboxylic acid .gamma.-lactones and congeners

Abstract: The preparation and valuable biological properties - especially diuretic activity - of 6.beta.,17-dihydroxy-7.alpha.-(lower alkoxy)carbonyl-3-oxo-17.alpha.-pregn-4-ene-21-carboxylic acid .gamma.-lactones and the corresponding hydroxy acids and salts thereof are disclosed.


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Inventors: Karim, Aziz (Niles, IL, US)
Marsheck, William J. (Harbor Beach, MI, US)
Weier, Richard M. (Deerfield, IL, US)

Application Number: 615412
Filing Date: 1975-09-22
Publication_date: 1976-08-03
Assignee: G. D. Searle & Co. (Chicago, IL)
Primary Class(es): 540/44 435/58, 435/911, 552/509, 552/615
Other Classes:
US Patent Ref:
3900467Aug, 1975Irmscher et al.260/239.

Other Refs:
Primary Examiner: Roberts, Elbert L.
Assistant Examiner:
Attorney: Cowley; Barbara L.