Title: Hydroxy phenylbutazone derivatives and their preparation

Abstract: Bis-hydroxyphenylbutazone esters of alkanedioic acids of the formula ##SPC1## Wherein n is an integer from 1 to 18, inclusive; R.sub.1 is hydrocarbon of 3-9 carbon atoms, optionally substituted by oxo or interrupted by thia, sulfinyl, or sulfonyl; and R.sub.2 is a hydrogen atom, a fluorine atom, a chlorine atom, lower alkyl of 1-4 carbon atoms, or trifluoromethyl, preferably in the ortho or para position, possess topical anti-inflammatory activity.

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Inventors: Rahtz, Dieter (Berlin, DT)
Koch, Henning (Berlin, DT)
Gerhards, Erich (Berlin, DT)

Application Number: 599397
Filing Date: 1975-07-28
Publication_date: 1976-07-06
Assignee: Schering Aktiengesellschaft (Berlin & Bergkamen, DT)
Primary Class(es): 514/404 548/365.1, 548/366.4, 548/367.1
Other Classes:
US Patent Ref:

3457273

Jul, 1969

Rumpf et al.

260/310.

Other Refs: 7,009,718

Jan, 1971	NL

Primary Examiner: Moyer, Donald B.
Assistant Examiner:
Attorney: Millen, Raptes & White