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Title: Drug delivery device
Abstract:
A drug delivery device for administering a drug at a controlled rate for a prolonged period of time to produce a local or systemic physiological or pharmacological effect is comprised of a wall surrounding a reservoir containing a drug. The reservoir is formed of a drug carrier permeable to the passage of the drug and in which the drug has limited solubility. The wall is formed in at least a part of a drug release rate controlling material also permeable to the passage of the drug, but the rate of passage of the drug through the wall is lower than the rate passage of the drug through the drug carrier so that drug release by the wall is the drug release rate controlling step for releasing drug from the drug delivery device.
Other info: Inventors: Zaffaroni, Alejandro (Atherton, CA, US) Application Number: 555840 Filing Date: 1975-03-06 Publication_date: 1976-07-06 Assignee: Alza Corporation (Palo Alto, CA) Primary Class(es): 128/833 424/424, 424/432, 424/435, 604/57, 604/515 Other Classes: US Patent Ref:
Other Refs: Other References: Unknown, "An Unusually Effective IUD Device That Has No Systemic Effects," Medical World News, May 25, 1973, pp. 55-56. Chang, et al., "Sustained Release Hormonal Preparations," Fertility & Sterility, vol. 21, No. 2, Feb., 1970, pp. 134-139. Kratochvil, et al., "Sustained Release Hormonal Preparations," Steroids, vol. 15, No. 4, Apr., 1970, pp. 505-511. | |