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Title: TLC method for drug detection
Abstract:
A simplified method of carrying out thin-layer chromatography for the detection of drugs. Neutral, basic amine-containing, and acidic drugs are extracted from a physiological medium with a salt-organic solvent system. The organic phase is then transferred incrementally to a small dish having a small adsorbent disc, with the organic solvent system evaporated between the incremental additions. When the organic extractant is substantially completely evaporated, the disc is then introduced into an available opening adjacent one end of a thin-layer chromatograph. The chromatograph is then developed employing a developing solution. After drying the chromatograph, the chromatograph is subjected to specific reagent treatment and developing processes, involving dipping, rather than spraying, to color the various spots and make them visible. In this manner, a physiological sample can be rapidly treated and the presence of a drug determined in accordance with its migration and coloration under reagent treatment.
Other info: Inventors: Jones, Donald W. (Auburn, CA, US) Application Number: 487957 Filing Date: 1974-07-12 Publication_date: 1976-06-15 Assignee: Sierra Laboratories, Inc. (Auburn, CA) Primary Class(es): 436/162 73/61.54, 210/658, 422/70, 436/92, 436/98, 436/111, 436/901 Other Classes: US Patent Ref:
Other Refs: Other References: "Isolation & Identification of Drugs," E. G. C. Clarke, ed., pp. 16-30, Pharmaceutical Press, London, 1969. | |