Title: Dibenzothiophene derivatives as serum lipid lowering agents

Abstract: A compound of the general formula ##SPC1## And pharmaceutically acceptable salts thereof, in which formula R.sup.0 is H, F, Cl, Br or OCH.sub.3 ; R.sup.1 and R.sup.2 are the same or different and selected from the group consisting of H and alkyl groups having 1-3 carbon atoms; R.sup.3 is H or an alkyl group having 1-3 carbon atoms; R.sup.0 and the side-chain containing the radicals R.sup.1, R.sup.2 and R.sup.3 being placed on the same or different benzene ring. Pharmaceutical preparations containing these compounds are useful in a method for lowering the serum lipid concentration in mammals, including man. These same preparations are also useful for the combined lowering of serum cholesterol and triglyceride concentrations.

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Inventors: Bondesson, Ulf Goran (Huddinge, SW)
Gronowitz, Salo Schmul (Lund, SW)
Stjernstrom, Nils Erik (Sodertalje, SW)
Svensson, Tage Rolf Gunnar (Lund, SW)

Application Number: 446621
Filing Date: 1974-02-28
Publication_date: 1976-04-27
Assignee: Aktiebolaget Astra (Sodertalje, SW)
Primary Class(es): 514/443 549/44
Other Classes:
US Patent Ref:

3293124	Dec, 1966	Bindler et al.	424/275.
3655697	Apr, 1972	Shen et al.	424/275.
3704245	Nov, 1972	Umio et al.	424/275.
3736334	May, 1973	Winter et al.	424/275.
3784602	Jan, 1974	Frei et al.	424/275.

Other Refs:
Primary Examiner: Turner, V. D.
Assistant Examiner: Clarke, Vera C.
Attorney: Brumbaugh, Graves, Donohue & Raymond