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Primary Examiner: Rose, Shep K.
Assistant Examiner:
Attorney: Yetter; Jerry J., Filcik; Julius P., Witte; Richard C.

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Title: Compositions for topical application to animal tissue and method of enhancing penetration thereof

Abstract: Disclosed are compositions for topical application to skin comprising an anticholinergic scopolamine ester in certain (C.sub.8 -C.sub.12) aliphatic sulfoxides which enhance the penetration of the anticholinergic scopolamine ester through skin.


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Inventors: MacMillan, Francis S. Kilmer (Cincinnati, OH, US)
Lyness, Warren I. (Cincinnati, OH, US)

Application Number: 541901
Filing Date: 1975-01-17
Publication_date: 1976-04-27
Assignee: The Procter & Gamble Company (Cincinnati, OH)
Primary Class(es): 514/304 424/65, 514/708, 514/947
Other Classes:
US Patent Ref:
3312709Apr, 1967Kilmer-MacMillan260/292.
3326768Jun, 1967Kilmer-MacMillan424/265.
3527864Sep, 1970Kilmer-MacMillan et al.424/337.
3678156Jul, 1972Kilmer-MacMillan et al.424/68.
3839566Oct, 1974Kilmer-MacMillan et al.424/337.
3903256Feb, 1975Kilmer-MacMillan et al.424/59.

Other Refs: Other References: F. S. Kilmer-MacMillan et al., J. Invest. Dermat. 43(5):363- 377, Nov. 1964, "The Antiperspirant Action of Topically Applied Anticholinergics."