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Title: Process for the preparation of the cephalosporanic acid derivative
Abstract:
A process for the preparation of cephalosporanic acid derivatives represented by the formula ##SPC1## Wherein R.sub.1 and R.sub.2, which may be the same or different, each represents a univalent group other than a hydrogen atom, said R.sub.1 and R.sub.2 may be combined to form a divalent group and A represents a divalent group represented by the formulae ##SPC2## Wherein R.sub.3 represents a hydrogen atom or a group which does not contribute to the reaction, which comprises heating a penicillin sulfoxide derivative represented by the formula ##SPC3## Wherein R.sub.1, R.sub.2 and R.sub.3 are as defined above. The cephalosporanic acid derivatives prepared by the process of this invention are useful as a starting material for the preparation of antibacterials.
Other info: Inventors: Murakami, Masuo (Tokyo, JA) Takahashi, Kozo (Tokyo, JA) Isaka, Ichiro (Hoya, JA) Ozasa, Teruaki (Ageo, JA) Kashiwagi, Teruya (Urawa, JA) Application Number: 426108 Filing Date: 1973-12-19 Publication_date: 1976-01-27 Assignee: Yamanouchi Pharmaceutical Co., Ltd. (Tokyo, JA) Primary Class(es): 540/218 Other Classes: US Patent Ref:
Other Refs: Other References: Spry, J. Am. Chem. Soc. 92(16), pp. 5006-5008 (8/12/70). | |