Title: Solid phase radioimmunoassay of digoxin

Abstract: Clinically significant concentrations of digoxin can be determined by reacting an unknown amount of digoxin, a known amount of labelled digoxin, and a composite consisting of anti-digoxin antibodies coupled through an intermediate silane to magnetically responsive particles; magnetically separating the immunochemical complexes formed thereby, counting the radioactivity of either the separated products or remaining solution, and relating the count to a standard curve.

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Inventors: Hersh, Leroy S. (Painted Post, NY, US)
Yaverbaum, Sidney (Big Flats, NY, US)

Application Number: 447251
Filing Date: 1974-03-01
Publication_date: 1976-01-20
Assignee: Corning Glass Works (Corning, NY)
Primary Class(es): 436/526 436/527, 436/804, 436/815, 436/817
Other Classes:
US Patent Ref:

3519538	Jul, 1970	Messing et al.	424/12.
3652761	Mar, 1972	Weetall	424/12.

Other Refs:
Primary Examiner: Padgett, Benjamin R.
Assistant Examiner: Nucker, Christine M.
Attorney: Giblin; James A., Janes, Jr.; Clinton S., Patty, Jr.; Clarence R.