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Title:
Liposome encapsulation of chelating agents
Abstract:
A method for transferring a chelating agent across a cellular membrane by encapsulating the charged chelating agent within liposomes and carrying the liposome-encapsulated chelating agent to the cellular membrane where the liposomes containing the chelating agent will be taken up by the cells, thereby transferring the chelating agent across the cellular membrane. A chelating agent can be introduced into the interior of a cell of a living organism wherein the liposomes will be decomposed, releasing the chelating agent to the interior of the cell. The released chelating agent will complex intracellularly deposited toxic heavy metals, permitting the more soluble metal complex to transfer across the cellular membrane from the cell and subsequently be removed from the living organism.
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Inventors:
Rahman, Yueh Erh (Downers Grove, IL, US)
Application Number:
415077
Filing Date: 1973-11-12 Publication_date: 1976-01-13 Assignee:
The United States of America as represented by the United States Energy (Washington, DC)
Primary Class(es):
514/574
Other Classes:
US Patent Ref:
Other Refs:
Other References:
rahman et al. -- Chem. Abst. Vol. 79, (1973), p. 49585q. Inchema -- Chem. Abst., Vol. 79, (1973), p. 45830t. |