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Primary Examiner: Gallagher, R.
Assistant Examiner:
Attorney: Rowe; James L., Smith; Everet F.

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Title: Preparation of N-2-(6-hydroxybenzothiazolyl)-N'-phenyl (or substituted-phenyl) ureas

Abstract: N-2-(6-hydroxybenzothiazolyl)-N'-phenyl (or substituted-phenyl) ureas are prepared by reacting 2-amino-6-hydroxybenzothiazole with 1-2 moles of phenyl (or a substituted phenyl) isocyanate and then hydrolysing any 6-phenylcarbamoyloxy compound thus produced to the corresponding 6-hydroxy derivative.

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Inventors: Lavagnino, Edward R. (Indianapolis, IN, US)
Paget, Charles J. (Indianapolis, IN, US)
Wikel, James H. (Greenwood, IN, US)

Application Number: 502130
Filing Date: 1974-08-30
Publication_date: 1976-01-13
Assignee: Eli Lilly and Company (Indianapolis, IN)
Primary Class(es): 548/163
Other Classes:
US Patent Ref:
Other Refs: Other References: dyer et al., J. Am. Chem. Soc., 81, 2138-2143 (1959).
Smith, The Chemistry of Open-Chain Organic Nitrogen Compounds, Vol. I. N.Y., Benjamin, 1965, p. 270.