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Primary Examiner: Sebastian, Leland A.
Assistant Examiner:
Attorney: Lane, Aitken, Dunner & Ziems

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Title: Method of preparation of a composition having a base of 99.sup.m technetium for diagnosis by scintigraphy

Abstract: A method for preparing a pyrophosphate-tin composition labelled with 99.sup.m technetium for medical diagnosis by scintigraphy, especially bone scintigraphy. A pyrophosphate solution and a freshly prepared stannous chloride solution are mixed together and then neutralized to a pH within the range of 5 to 7, the mixture is eventually lyophilized in order to obtain a pyrophosphate-tin complex in powder form which is then mixed with a solution containing 99.sup.m Tc, the last-mentioned final step of the method being carried out at the moment of use. The complex has a pyrophosphate-tin molecular ratio of at least 30. CROSS-REFERENCE TO RELATED APPLICATION:


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Inventors: Bardy, Andre (Morangis, FR)
Beydon, Jacqueline (Paris, FR)

Application Number: 455005
Filing Date: 1974-03-26
Publication_date: 1976-01-06
Assignee: Commissariat a l'Energie Atomique (Paris, FR)
Primary Class(es): 424/1.61 206/524.8, 206/828, 250/303, 423/249, 424/604, 424/606, 424/650
Other Classes:
US Patent Ref:
Other Refs: Other References: Subramanian et al., Radiology, Vol. 99, No. 1, pp. 192 to 196, (Apr. 1971).