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Title: Process for preparing o-nitrobenzylketones

Abstract: o-nitrobenzylketones are prepared by reacting a trans-.beta.-substituted amino-2-nitrostyrene with a lower alkanoyl halide, halo-lower alkanoyl halide, phthalimido-lower alkanoyl halide, benzoyl halide or substituted benzoyl halide, and subsequently hydrolyzing the resulting product to yield the desired o-nitrobenzylketone.


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Inventors: Fryer, Rodney Ian (North Caldwell, NJ, US)
Garcia, Edward Ernest (West Caldwell, NJ, US)

Application Number: 435050
Filing Date: 1974-01-21
Publication_date: 1976-01-06
Assignee: Hoffmann-La Roche Inc. (Nutley, NJ)
Primary Class(es): 548/479 548/477, 564/342, 564/383, 568/306
Other Classes:
US Patent Ref:
Other Refs:
Primary Examiner: Gotts, Lewis
Assistant Examiner: Williams, S. P.
Attorney: Welt; Samuel L., Leon; Bernard S., Isgro; William G.