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Primary Examiner: Randolph, John D.
Assistant Examiner:
Attorney: Stein; William J., Retter; Eugene O., Rauchfuss, Jr.; George W.

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Title: Process for preparing 2-azacycloalkylmethyl ketones

Abstract: A process for the preparation of 2-azacycloalkylmethyl ketones by chelating a methyl ketone with magnesium methyl carbonate and condensing the chelate with a 1-azacycloalkene in an atmosphere of carbon dioxide. The novel compounds described are useful anticoagulants.


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Inventors: Grisar, J. Martin (Cincinnati, OH, US)
Claxton, George P. (Cincinnati, OH, US)

Application Number: 354206
Filing Date: 1973-04-25
Publication_date: 1976-01-06
Assignee: Richardson-Merrell Inc. (Wilton, CT)
Primary Class(es): 540/596 514/822, 540/602, 540/603, 540/610, 546/196, 546/199, 546/202, 546/203, 546/204, 546/208, 546/209, 546/210, 546/211, 546/214, 546/237, 546/248, 548/525, 54
Other Classes:
US Patent Ref:
3316272Apr, 1967Roberts et al.260/240.
3853855Dec, 1974Grisar et al.260/240.
3882104May, 1975Grisar et al.260/240.

Other Refs: Other References: Claxton et al., J. Med. Chem., Vol. 15, pp. 500 to 503 (1972).
Uhlemann, Chemical Abstracts, Vol. 56, Col. 10092 (1962).